Background: Chronic actinic dermatitis is a photosensitivity disorder with scant epidemiologic data. Case series in Europe have previously shown that improvement or resolution of chronic actinic dermatitis occurs over time in most patients. However, the natural history of chronic actinic dermatitis in patients in the United States has not been studied.
Objective: To study the natural history of chronic actinic dermatitis in patients in the United States.
Methods: We performed a retrospective chart review and telephone questionnaire after a 3- to 19-year follow-up period.
Results: Of 20 patients with chronic actinic dermatitis, 7 patients (35%) experienced resolution and an additional 11 patients (55%) experienced improvement of their photosensitivity to sunlight during the follow-up period. The proportion of patients experiencing improvement or resolution of their chronic actinic dermatitis increased at 5, 10, and 15 years after diagnosis.
Conclusions: Our study demonstrates that abnormal photosensitivity to sunlight in chronic actinic dermatitis improves or resolves over time in most patients in New York. The rates of improvement or resolution in our patients in New York are similar to the rates in case series in Europe despite likely patient demographic differences.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/DER.0000000000000007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the Therapeutic Landscape: A Narrative Review on Topical and Oral Phosphodiesterase-4 Inhibitors in Dermatology.
Pharmaceutics
January 2025
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Phosphodiesterase-4 (PDE4) is involved in the synthesis of inflammatory cytokines that mediate several chronic inflammatory disorders, including psoriasis and atopic dermatitis. In recent years, the therapeutic armamentarium in dermatology has expanded with the introduction of PDE4 inhibitors, both in oral and topical formulations. PDE4 inhibitors have gained increasing interest due to their remarkable safety record and ease of prescription, as evidenced by the recent influx of literature detailing its off-label uses.
View Article and Find Full Text PDFA survey of lip lesions diagnosed in a single institution: A clinicopathological study.
J Clin Exp Dent
December 2024
School of Dentistry, Department of Clinical and Preventive Dentistry, Oral Pathology Unit, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Background: The aim of this study was to assess the clinicopathological features of lip lesions diagnosed in a single Oral Pathology service in Brazil.
Material And Methods: It was a cross-sectional study based on secondary data. Between 2000 and 2019, all lip lesions diagnosed in an Oral Pathology service in Brazil were analyzed.
Daylight Photodynamic Therapy: At-Home Delivery.
J Clin Med
December 2024
School of Medicine, University of Dundee, Dundee DD1 4HN, UK.
This pilot study evaluated the design, usability, and practicality of the dPDT@home kit for treating actinic keratoses (AKs) on the face and scalp. The kit allowed patients to manage their treatment at home, reducing hospital visits and utilizing natural sunlight. While patients were very willing to use the kit again, further studies are required to evaluate outcomes and ascertain the need for additional improvements and support.
View Article and Find Full Text PDFChronic actinic dermatitis as a diagnostic clue for adult T-cell leukemia/lymphoma.
JAAD Case Rep
January 2025
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Single Nucleotide Polymorphisms on Toll-like Receptor-4 and the Risk of Developing Skin Cancer.
Int J Mol Sci
November 2024
Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard VH566A, Birmingham, AL 35294, USA.
Exposure to solar ultraviolet (UV) radiation is an established risk factor for skin cancer. Toll-like receptor-4 (TLR4)-mediated immune dysregulation has emerged as a key mechanism for the detrimental effects of acute and chronic UV exposure and skin cancer in mice. Single nucleotide polymorphisms (SNPs) on the gene have been reported to increase or decrease susceptibility to various cancers in other organs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!