En bloc resection with negative tumor margins remains the principal treatment option for control or cure of primary pelvic chondrosarcomas, as current adjuvant therapies remain ineffective. Iliosacral chondrosarcomas with involvement of the sciatic notch are sufficiently challenging tumors. However, when there is concomitant lumbar extension requiring resection of the pedicles to maintain negative surgical margins, transpedicular screw fixation is not possible, making reconstruction of the lumbopelvic junction extremely challenging. A patient with an iliosacral chondrosarcoma with lumbar spine extension is presented in this report to illustrate a novel lumbopelvic spinal construct. Following combined external pelvectomy and hemisacrectomy with contralateral L3-5 hemilaminectomy and ipsilateral pediculotomy, bicortical transvertebral body screws were substituted for the missing pedicles, resulting in the creation of "false pedicles," which were further supplemented with an autologous vascularized fibular strut graft from the amputated lower limb and applied to the lateral aspect of the vertebral bodies. The creation of false pedicles allowed for a robust reconstruction of the lumbopelvic junction, including maintaining pelvic ring integrity with a "neo-pelvis", creating a functional load-bearing construct adequate for early mobilization and ambulation. The biomechanical dynamics of this unique construct are also discussed.
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http://dx.doi.org/10.3171/2013.11.SPINE13211 | DOI Listing |
J Pediatr Urol
December 2024
Division of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL 60610, United States. Electronic address:
Background: Continent catheterizable channels (CCC) are a mainstay for reconstruction in patients with neurogenic bladders. Common complications include false passage, channel stenosis/difficult catheterization, channel incontinence, and stomal stenosis. This may result in the need for surgical revision or replacement.
View Article and Find Full Text PDFPLoS One
December 2024
Centro de Investigación en Computación (CIC), Instituto Politécnico Nacional, Ciudad de México, México.
Informal education via social media plays a crucial role in modern learning, offering self-directed and community-driven opportunities to gain knowledge, skills, and attitudes beyond traditional educational settings. These platforms provide access to a broad range of learning materials, such as tutorials, blogs, forums, and interactive content, making education more accessible and tailored to individual interests and needs. However, challenges like information overload and the spread of misinformation highlight the importance of digital literacy in ensuring users can critically evaluate the credibility of information.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, 200032, China.
N6-methyladenosine (mA) serves as one of the crucial RNA modifications for genes involved in cancer progression. Here, 7273 expression quantitative trait loci potentially regulating 30 m6A pathway genes are identified from the GTEx database, with 69 single nucleotide polymorphisms significantly associated with survival of non-small cell lung carcinoma (NSCLC) patients (n = 1523) from the ongoing genome-wide association study after false positive probability tests. Notably, the rs151198415 locus, situated in a potential enhancer region, demonstrated a prolonged survival effect with the C>CCACG insertion, which is validated in an independent prospective cohort (n = 237), yielding a pooled hazard ratio of 0.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
The Arctic University Museum of Norway, UiT - The Arctic University of Norway, Lars Thørings veg 10, 9006 Tromsø, Norway.
We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to a new server and the creation of a computational mirror, we have expanded the database with the addition of 33 invertebrate species, including representatives of 5 previously unsampled phyla, and 6 mammal species.
View Article and Find Full Text PDFAnalyst
December 2024
Department of Laboratory Medicine, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, No. 9 Tujialing, Dingziqiao Road, Wuchang District, Wuhan, Hubei province, 430064, China.
Cell-free DNA (cfDNA) has attracted increasing attention as a promising biomarker in liquid biopsy due to its crucial role in disease diagnosis. However, previous cfDNA detection methods are commonly based on the development of target-specific primers and integrated signal amplification strategies, which may induce false-positive results. This paper presents a sensitive yet accurate method for cfDNA detection that combines phosphorothioated-terminal hairpin creation with a self-priming extension process.
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