AI Article Synopsis
- CD36 is identified as a receptor for infected red blood cells and oxLDL, which may play a significant role in the infection process of Plasmodium falciparum.
- The study aimed to assess how high levels of oxLDL affect CD36 in red blood cells of diabetic patients, with a focus on those with severe diabetes indicated by high HbA1c levels.
- Results showed that elevated oxLDL concentrations significantly impact the activity of CD36, potentially aiding the survival of malaria parasites by preventing their removal from the body by the immune system.
Article Abstract
Background: Cluster of differentiation 36 (CD36) is reported to function as a receptor of erythrocytes infected with Plasmodium falciparum (PF) and as an oxidized low-density lipoprotein (oxLDL).
Aim: The aim of this study was to investigate the impact of CD36 in PF parasitized red blood cells in high concentration of oxLDL of T2 diabetes mellitus patients.
Material And Methods: This cross-sectional study was conducted among diabetic patients. A total of 45 samples were collected from diabetic patients with more than 8% of HbA1c and more than 170 mg/dL of oxLDL.
Results: The mean difference between CD36 negative and positive controls was found to be statistically significant (P ≤ 0.001). The mean difference between CD36 positive control and CD36 in diabetic patients with oxLDL ≥ 170 mg/dL also was statistically significant.
Conclusion: High concentration of oxidative low density of lipoprotein more than 170 mg/dL leads to block CD36 receptor on infected red blood. This process believed to contribute in parasite survival by avoiding phagocytic clearance in the spleen.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877532 | PMC |
| http://dx.doi.org/10.4103/1947-2714.123255 | DOI Listing |
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