AI Article Synopsis
- A new melphalan hemoperfusion filter (GEN 2) was tested in pigs to assess its effectiveness in filtering melphalan during a simulated medical procedure.
- The filter showed a high efficiency of 99.0% in removing melphalan and maintained a low pressure gradient of 20.9 mmHg, indicating good blood flow.
- Although some blood components like albumin and platelets decreased during the procedure, the changes are considered manageable in a clinical setting.
Article Abstract
Purpose: A new melphalan hemoperfusion filter (GEN 2) was evaluated in a simulated-use porcine model of percutaneous hepatic perfusion (PHP). The current study evaluated melphalan filtration efficiency, the transfilter pressure gradient, and the removal of specific blood products.
Materials And Methods: A porcine PHP procedure using the GEN 2 filter was performed under Good Laboratory Practice conditions to model the 60-min clinical PHP procedure.
Results: The mean filter efficiency for removing melphalan in six filters was 99.0 ± 0.4 %. The transfilter pressure gradient across the filter averaged 20.9 mmHg for the 60-min procedure. Many blood components, including albumin and platelets, decreased on average from 3.55 to 2.02 g/dL and from 342 to 177 × 10.e3/μL, respectively, during the procedure.
Conclusion: The increased melphalan extraction efficiency of the new filter is expected to decrease systemic melphalan exposure. In addition, the low transfilter pressure gradient resulted in low resistance to blood flow in the GEN 2 filter, and the changes to blood components are expected to be clinically manageable.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024156 | PMC |
| http://dx.doi.org/10.1007/s00270-013-0826-5 | DOI Listing |
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