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Anti-PD1-/PDL1-induced chronic intestinal pseudo-obstruction: three cases treated with vedolizumab after corticosteroid failure with mixed results.
Cancer Immunol Immunother
January 2025
Department of Medical Oncology, Institut de Cancérologie de L'Ouest, 44805, Saint Herblain, France.
Immune checkpoint inhibitors (ICI), i.e., anti-PD1/PDL1 and anti-CTLA-4, have reshaped the prognosis of many cancers.
View Article and Find Full Text PDFUnusual Causes of Death Due to Constipation.
Am J Forensic Med Pathol
December 2024
Forensic Pathology Unit, Royal Darwin Hospital, Darwin, Northern Territory and College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Constipation is found in individuals with intellectual disabilities, autism, and cerebral palsy. Although generally a benign condition, it may lead to life-threatening intestinal obstruction, with or without volvulus, or to stercoral ulceration with enteritis and/or perforation. Two unusual cases of lethal chronic constipation are reported to demonstrate other very rare fatal mechanisms that may occur.
View Article and Find Full Text PDFTwist of fate: Resolving cecal volvulus with timely surgical intervention in a middle-aged female.
Int J Surg Case Rep
November 2024
The Department of Surgery, American Hospital in Dubai, United Arab Emirates. Electronic address:
Introduction And Importance: Cecal volvulus is an uncommon cause of large bowel obstruction that typically presents in older adults with a history of chronic constipation or prior abdominal surgery. However, this report documents a rare and atypical case of cecal volvulus presenting in a middle-aged female with no significant past medical or surgical history. This case also highlights the benefits of adopting a synergistic approach between a physician's clinical judgment and the patient's presentation when making a diagnosis to ensure timely interventions and prevent life-threatening complications.
View Article and Find Full Text PDFAcute Hemorrhagic Rectal Ulcer Presenting With Severe Lower Gastrointestinal Bleeding: A Case Report of an Emerging Entity.
Cureus
November 2024
Gastroenterology and Hepatology, American University of Beirut, Beirut, LBN.
Acute hemorrhagic rectal ulcer (AHRU) is a rare but potentially life-threatening condition. We present the case of a 74-year-old man who developed sudden massive hematochezia and hypotension during hospitalization for fever of unknown origin. He was known to have alcohol-related liver cirrhosis, hypoalbuminemia and coronary artery disease (CAD) and was on daily aspirin.
View Article and Find Full Text PDFA rare case report of ileosigmoid knots that cause intestinal obstruction during Ramadan fasting.
Int J Surg Case Rep
December 2024
Department of Visceral and Digestive Surgery, Monastir University Hospital, Monastir, Tunisia.
Introduction And Importance: This case report aims to highlight the clinical presentation, diagnostic challenges, surgical intervention, and subsequent management strategies of ISK during Ramadan fasting.
Case Presentation: 52-Year-old male with a three-day history of symptoms of intestinal obstruction. He complained of abdominal distention, vomiting, and absolute constipation.
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