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Schistosoma mansoni infection after three years of mass drug administration in Sierra Leone. | LitMetric

AI Article Synopsis

  • Schistosoma mansoni, a tropical parasite, was widespread in northeast Sierra Leone, prompting a national program to begin mass drug administration (MDA) of praziquantel starting in 2009, aimed at primary school children and later expanding to other groups.
  • A 2012 survey evaluated the program's impact, involving the examination of stool samples from school children across 26 randomly chosen sites according to their baseline prevalence of infection.
  • Results showed a significant reduction in infection rates, with overall prevalence decreasing from baseline levels, leading to a review of the treatment strategy to further include children in less affected areas.

Article Abstract

Background: Schistosoma mansoni was moderately-highly endemic in the northeast of Sierra Leone. The national neglected tropical disease control program started mass drug administration (MDA) with praziquantel (PZQ) in six districts in 2009 targeting primary school children only. The effort was scaled-up to seven districts in 2010 targeting school aged children (SAC) and at-risk adults. A cross-sectional sentinel site survey was conducted in 2012 after three rounds of MDA to evaluate the impact of the national program.

Methods: Twenty-six (26) sentinel sites were randomly selected from the baseline mapping survey sites stratified according to the baseline prevalence into high, moderate or low endemic category. Fifty (50) school children (25 males and 25 females) were randomly selected per site. Fresh stool samples were examined in the field using the Kato Katz technique. The results were compared with the baseline data.

Results: Program coverage of 94.8%, 77.1% and 81.7% was reported in 2009, 2010 and 2011 respectively. Independent monitoring in 2011 showed program coverage of 83.9%, not significantly different from the reported result in the same year. The overall prevalence of S. mansoni was 16.3% (95% CI: 14.4-18.4%) and mean intensity was 18.98 epg (95% CI: 11.46-26.50 epg) in 2012, representing 67.2% and 85.9% reduction from the baseline respectively. The proportion of moderately and heavily infected children was 3.3% and 1.2%, a significant reduction from 18.2% and 8.8% at baseline respectively.

Conclusions: Sierra Leone has maintained effective MDA coverage with PZQ since 2009. Three rounds of MDA led to a significant reduction of S. mansoni infection in the country. In line with the significant progress made in controlling schistosomiasis, the national treatment strategy has been reviewed and MDA will be expanded to include school age children in low endemicity districts with the new national objective for the elimination of schistosomiasis. Sierra Leone is well on its way to eliminate schistosomiasis as a public health problem.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895768PMC
http://dx.doi.org/10.1186/1756-3305-7-14DOI Listing

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