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A first-in-human phase 1/2 dose-escalation study of MAK683 (EED inhibitor) in patients with advanced malignancies.
Eur J Cancer
November 2024
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Purpose: MAK683, a first-in-class and highly selective allosteric inhibitor of the embryonic ectoderm development subunit of polycomb repressive complex 2, has shown sustained antitumor activity in tumor xenograft models. This first-in-human phase 1/2 study evaluated the safety, pharmacokinetics (PK), and clinical activity of single-agent MAK683 in advanced malignancies.
Methods: MAK683 was administered fasted once daily or twice daily continuously in 28-day treatment cycles.
Influence of mesh selectivity on risk assessment of marine microplastics.
Mar Pollut Bull
January 2025
Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-Ku, Tokyo 108-8477, Japan. Electronic address:
In this study, environmental microplastic samples (>30 μm) were collected from surface seawater and the water column, characterized, and used to assess ecological risks. The influence of mesh selectivity on ecological risks was also evaluated through subsampling. Results show that surface microplastic concentrations (>30 μm) range from 92 to 3306 pieces/m along Japan's southwest coast, with significant increases at Stas.
View Article and Find Full Text PDFInvestigation of Teicoplanin Trough Concentrations and Safety Following High-Dose Loading in a Pediatric Population.
Ther Drug Monit
January 2025
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Background: Therapeutic drug monitoring-informed teicoplanin dosage adjustments are recommended for safe and effective use. The authors' group previously reported that only half of children reached the recommended blood concentration range at the standard teicoplanin loading dose. It has been suggested that higher loading doses are necessary; however, the usefulness and safety of high-dose loading in pediatric patients in clinical practice are unknown.
View Article and Find Full Text PDFLarge Polarization Change Induced by Spin Crossover-Driven Fe(II) Ion Shuttling within a Tripodal Ligand.
J Am Chem Soc
January 2025
Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
The integration of spin crossover (SCO) magnetic switching and electric polarization properties can engender intriguing correlated magnetic and electric phenomena. However, achieving substantial SCO-induced polarization change through rational molecular design remains a formidable challenge. Herein, we present a polar Fe(II) compound that exhibits substantial polarization change in response to a thermally regulated low-spin ↔ high-spin transition.
View Article and Find Full Text PDFThe impact of air pollution control measures and the COVID-19 pandemic on photosynthesis in urban trees.
Sci Rep
January 2025
Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.
Phytotoxic air pollutants such as atmospheric nitrogen dioxide (NO) are among the major stresses affecting tree photosynthesis in urban areas. We clarified the relationship between NO concentrations and photosynthetic function for three major urban trees, Prunus × yedoensis, Rhododendron pulchrum, and Ginkgo biloba, planted in Kyoto and surrounding cities, combining our published data and new data collected from 2020 to 2023. High NO increased long-term water use efficiency for all species.
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