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The Predictors, Motivations and Characteristics of Image-Based Sexual Abuse: A Scoping Review.
Trauma Violence Abuse
March 2025
University of Sheffield, Sheffield, UK.
Image-based sexual abuse (IBSA) is a form of sexual violence and abuse that is facilitated by the use of technology. The array of different technologies, ever-changing behaviors, and varied terminology have created challenges in terms of appropriate response, legislation, and the protection of victims as well as difficulties in establishing the extent and harms of this behavior on a wider scale and context. This scoping review examines and synthesizes the current literature which focuses on predictors, the motivation of perpetrators, and the characteristics of both victims and perpetrators in relation to IBSA.
View Article and Find Full Text PDFHuman BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.
Nat Methods
March 2025
Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN, USA.
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate Framework (CCF), knowledge graphs and tools that describe the multiscale structure of the human body (from organs and tissues down to cells, genes and biomarkers) and to use the HRA to characterize changes that occur with aging, disease and other perturbations. HRA v.
View Article and Find Full Text PDFMechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.
EXCLI J
February 2025
Molecular Hepatology Section, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Non-alcoholic Fatty Liver Disease (NAFLD) - whose terminology was recently replaced by metabolic liver disease (MAFLD) - is an accumulation of triglycerides in the liver of >5 % of its weight. Epidemiological studies indicated an association between NAFLD and reduced physical activity. In addition, exercise has been shown to improve NAFLD independently of weight loss.
View Article and Find Full Text PDFAdverse events to elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis due to elevated drug exposure?: A case series.
J Cyst Fibros
March 2025
Central Hospital Pharmacy (Laboratory AHZ), Charlotte Jacobslaan 70, 2545 AB The Hague, the Netherlands.
Background: Recent studies revealed that some people with cystic fibrosis (pwCF) receiving the full dose of Elexacaftor/Tezacaftor/Ivacaftor (ETI) experience adverse events (AEs), leading to discontinuation or dose adjustments of their modulator treatment. We aimed to investigate if pwCF who experienced AEs had high exposure to ETI, and to what extent dose reduction resulted in changes in exposure, side effects and efficacy.
Method: This retrospective case series presents ETI exposure in pwCF who required ETI dose reduction due to AEs.
Two Japanese Cases of Breast Cancer That Developed Pembrolizumab-Induced Adrenal Insufficiency and Literature Review.
Cureus
February 2025
Breast and Thyroid Surgery, Kitasato University Hospital, Sagamihara, JPN.
We report two cases of adrenal insufficiency (AI) occurring during neoadjuvant treatment with pembrolizumab for breast cancer. In the first case, a 53-year-old female presented with a chief complaint of poor oral intake and fatigue. In the second case, a 46-year-old female presented with a chief complaint of fever, poor oral intake, and general fatigue and was admitted with a diagnosis of pneumonia.
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