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Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency.
Drug Des Devel Ther
November 2024
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, People's Republic of China.
Article Synopsis
- This study aimed to compare the effectiveness and safety of linezolid versus teicoplanin in treating hospital-acquired pneumonia (HAP) caused by Gram-positive bacteria in patients with renal issues.
- The results showed that linezolid achieved a significantly higher bacterial eradication rate (88.5% vs 63.4%) but also led to more adverse reactions (42.0% vs 25.0%).
- The optimal dosage strategy for linezolid was determined, recommending 300 mg every 12 hours for patients with better renal function and 200 mg for those with more severe renal insufficiency.
Safety and efficacy of personalised versus standard dosing of linezolid in patients with sepsis (SePkLin): a pragmatic, multicentre, randomised, controlled and superiority clinical trial protocol.
BMJ Open
October 2024
Consellería de Sanidade e o Servizo Galego de Saúde, Santiago de Compostela, Spain.
Introduction: Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positive bacteria. Therapeutic drug monitoring of linezolid concentrations is recommended to maximise its efficacy and safety, mainly haematological toxicity. Different pharmacokinetic/pharmacodynamic targets have been proposed to improve linezolid exposure: the ratio of the area under the concentration-time curve during a 24-hour period to minimum inhibitory concentration (MIC) between 80 and 120; percentage of time that the drug concentration remains above the MIC during a dosing interval greater than 85% and the trough concentration between 2 and 7 mg/L.
View Article and Find Full Text PDFBactericidal versus bacteriostatic antibacterials: clinical significance, differences and synergistic potential in clinical practice.
J Antimicrob Chemother
January 2025
School of Medicine, European University Cyprus, 6 Diogenes str, Nicosia 2404, Cyprus.
Antibacterial activity can be classified as either bactericidal or bacteriostatic, using methods such as the MBC/MIC ratio and time-kill curves. However, such categorization has proven challenging in clinical practice, as these definitions only apply under specific laboratory conditions, which may differ from clinical settings. Several factors, such as the specific bacteria or infectious medium, can affect the action of antibiotics, with many antibacterials exerting both activities.
View Article and Find Full Text PDFIntravenous Versus Oral Omadacycline or Linezolid for Acute Bacterial Skin and Skin Infections: A post hoc Analysis of the OASIS Trials.
Infect Dis Ther
December 2024
Paratek Pharmaceuticals, Inc., 1000 First Avenue, Suite 200, King of Prussia, PA, 19406, USA.
Article Synopsis
- The text discusses the challenges of oral antibiotic treatment for acute bacterial skin infections, highlighting that existing guidelines do not adequately address common skin pathogens.
- A post hoc analysis of two phase 3 clinical trials (OASIS-1 and OASIS-2) compares the safety and efficacy of starting treatment with intravenous (IV) therapy versus oral (PO) therapy using omadacycline or linezolid.
- Results show that both treatment methods are similarly effective, with comparable rates of early clinical response and adverse events, suggesting oral therapy is a viable option for treating these infections.
Linezolid Pharmacokinetics in Critically Ill Patients: Continuous Versus Intermittent Infusion.
Antibiotics (Basel)
October 2024
Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
Article Synopsis
- Linezolid shows significant variability in critically ill patients, affecting its plasma concentration and potentially its effectiveness, prompting the need for optimized dosing strategies.
- A study was conducted comparing two administration methods (intermittent infusion vs. continuous infusion) to assess their impact on pharmacokinetics and drug concentration in critically ill patients.
- Results indicated that continuous infusion led to more stable serum concentrations and better adherence to desired pharmacokinetic/pharmacodynamic indices, suggesting it could improve patient safety and outcomes compared to intermittent infusion.
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