AI Article Synopsis
- The study investigated the relationship between homocysteine levels, folic acid, and vitamin B12 in breast cancer patients undergoing chemotherapy.
- Results showed that during chemotherapy, homocysteine and vitamin B12 levels increased, while folate and platelet counts decreased significantly.
- A notable correlation was found between menopausal status and increased homocysteine levels, indicating a heightened risk for thromboembolic events in these patients.
Article Abstract
Background: Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data.
Methods: Thirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS.
Results: During chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase.
Conclusions: Evaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807486 | PMC |
| http://dx.doi.org/10.1002/jcla.21660 | DOI Listing |
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