AI Article Synopsis
- A total of 226 patients with advanced or recurrent colorectal cancer were treated using hyperthermia or immunotherapy from July 2005 to September 2012, resulting in clinical benefits for 30 patients (13.3%).
- Among the effectively treated patients, 5 experienced complete responses, and hyperthermia improved the immunotherapy effective rate from 14.3% to 16.1%.
- Notably, 4 patients had disappearing metastases in either the liver or lungs, demonstrating the potential effectiveness of these treatments in combating solid organ metastases.
Article Abstract
We treated 226 patients with advanced or recurrent colorectal cancer using hyperthermia or immunotherapy between July 2005 and September 2012. Clinical benefit (complete response [CR], partial response [PR], and long stable disease [SD] for more than 6 months) was observed in 30 patients (13.3%), including CR in 5 patients. The effective rate of immunotherapy increased from 14.3% to 16.1% using hyperthermia. The effective rate of hyperthermia was 3.9%. Of the 30 effectively treated patients, liver metastases disappeared in 2 patients treated with hyperthermia alone, and lung metastases disappeared in 2 patients treated with immunotherapy alone. In the remaining 26 effectively treated patients, multiple metastases were observed in solid organs. Both hyperthermia and immunotherapy were administered and were found to be effective in the treatment of patients with advanced or recurrent colorectal cancer.
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