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The refined CYP2B6-Template system for studies of its ligand metabolisms.
Drug Metab Pharmacokinet
November 2024
Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
The previously reported Template system for the prediction of human CYP2B6-mediated reactions (Drug Metab Pharmacokinet 26 309-330, 2011) has been refined with the introduction of ideas of allowable width, Trigger-residue and the residue-initiated movement of ligands in the active site. The refined system also includes ideas of bi-molecule binding on Template. With the use of these ideas in common with other Template systems for human CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, and CYP3A4, 360 reactions of 261 distinct chemicals reported as CYP2B6 ligands were examined in the refined system.
View Article and Find Full Text PDFHeme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response.
iScience
January 2025
Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Heme is known to bind to the intrinsically disordered region (IDR) to regulate protein function. The binding of heme to the IDR of transcription factor BACH2 promotes plasma cell differentiation, but the molecular basis is unknown. Heme was found to increase BACH2 IDR interaction with TANK-binding kinase 1 (TBK1).
View Article and Find Full Text PDFGarlic ( L.) Organosulfur Compounds Inhibit Breast Cancer Cell Proliferation by Decreasing Steroid Sulfatase Levels.
Anticancer Res
January 2025
Faculty of Pharmacy, Iryo Sosei University, Fukushima, Japan.
Background/aim: Breast cancer is mostly affected by estrogen, which promotes proliferation, tumorigenesis, and cancer progression. Estrogen sulfotransferase (SULT1E1) catalyzes sulfation to inactivate estrogens, whereas steroid sulfatase (STS) catalyzes estrogen sulfate hydrolysis to activate estrogens in breast cancer cells. Three major organosulfur compounds in garlic (Allium sativum L.
View Article and Find Full Text PDFComparison of activated sludge and virus interactions in aerobic and anaerobic membrane bioreactors.
iScience
December 2024
Shaanxi Key Laboratory of Environmental Engineering, School of Environmental and Municipal Engineering, Xi'an University Architecture and Technology, No. 13 Yanta Road, Xi'an 710055, P.R. China.
Membrane bioreactors (MBRs) are effective sewage treatment technologies, yet the differences in virus removal efficiency between aerobic (AeMBR) and anaerobic membrane bioreactors (AnMBR), remain inadequately understood. This study compared the virus removal efficiency of AeMBR and AnMBR, focusing on the interactions between aerobic (AeS) and anaerobic (AnS) activated sludge and viruses in the sewage treatment process. Results showed average log removal values (LRVs) for MS2 of 2.
View Article and Find Full Text PDFPre-immunization of diet-induced obese male mice with inactivated pathogens increases power in a liraglutide intervention study.
Lab Anim
December 2024
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Pre-immunization with inactivated antigens has been developed as an alternative to the use of 'dirty' mice, which in contrast to specific pathogen free (SPF) mice, harbour a range of pathogens. Within certain research areas, such mice are considered better models for humans than SPF mice, as they have an immune system that better mirrors human immunity. We inactivated murine adenovirus type 1 (FL), minute virus of mice, mouse hepatitis virus (A59), respirovirus muris (Sendai), Theiler's encephalomyelitis virus (GD7) and by ultraviolet irradiation.
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