AI Article Synopsis
- * Waltheriones A and C demonstrated noteworthy anti-HIV effects in lab tests, effectively protecting cells at certain concentrations and inhibiting HIV P24 formation by over 50%.
- * The structures of the identified alkaloids were confirmed using spectroscopic data analysis.
Article Abstract
The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 μM, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931125 | PMC |
| http://dx.doi.org/10.1021/np400847t | DOI Listing |
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