The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867664 | PMC |
| http://dx.doi.org/10.3389/fncel.2013.00269 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hybrid optimization enabled DenseNet for autism spectrum disorders using MRI image.
Comput Biol Chem
December 2024
School of Computing and Information Technology, REVA University, Bengaluru, India.
Autism spectrum disorder (ASD) is the neuro-developmental disorder caused by various changes in the brain. It affects the life conditions with social interaction and communication. Most of the previous researches used the various techniques for the early detection to reduce the ASD, but it had been occurred several complications such as, time expenses, and low accessibility for diagnosis.
View Article and Find Full Text PDFDiffering Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.
Brain Sci
December 2024
Division of Basic Biomedical Sciences & Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Background: It is known that being the adult child of a parent with an alcohol use disorder (ACoA) can confer a wide variety of increased health and psychological risks, including higher rates of anxiety, depression, and post-traumatic stress disorder symptoms. Additionally, ACoAs are at greater risk of developing alcohol/substance use disorders (AUDs/SUDs) than individuals from families without a history of AUDs.
Methods: ACoA individuals with risky hazardous alcohol use ( = 14) and those not engaged in hazardous use ( = 14) were compared to a group of healthy controls.
Cost-effectiveness of the SMILE intervention compared with usual care for people with severe mental illness: A randomized clinical trial.
PLoS One
January 2025
Department of Health Sciences, Vrije Universiteit Amsterdam, Faculty of Science, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Objectives: Only studying effectiveness of lifestyle interventions for people with severe mental illness (SMI) is insufficient for policy making. As budgets for healthcare are limited, policy makers face the problem of allocating scarce healthcare resources. Cost-effectiveness studies are needed, but currently cost-effectiveness studies of lifestyle interventions for people with SMI delivered in ambulatory care are limited.
View Article and Find Full Text PDFDynamics of affect modulation in neurodevelopmental disorders (DynAMoND) - study design of a prospective cohort study.
Int J Bipolar Disord
December 2024
Department for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.
Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuro-developmental disorder that often persists into adulthood. Moreover, it is frequently accompanied by bipolar disorder (BD) as well as borderline personality disorder (BPD). It is unclear whether these disorders share underlying pathomechanisms, given that all three are characterized by alterations in affective states, either long or short-term.
View Article and Find Full Text PDFDevelopment of KCC2 therapeutics to treat neurological disorders.
Front Mol Neurosci
December 2024
Axonis Therapeutics Inc., Boston, MA, United States.
KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS. Herein, we highlight KCC2 hypofunction as a fundamental and conserved pathology contributing to neuronal circuit excitation/inhibition (E/I) imbalances that underly epilepsies, chronic pain, neuro-developmental/-traumatic/-degenerative/-psychiatric disorders. Indeed, downstream of both acquired and genetic factors, multiple pathologies (e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!