Objectives/hypothesis: Facial transplantation has progressed over the past 8 years. We did the first Belgian facial transplantation by vascularized composite tissue allotransplantation and report the 1-year follow-up regarding speech and oromyofunctional behavior.
Study Design: Outcome study.
Methods: The recipient, a 56-year-old man, had his face severely injured due to a ballistic injury. In January 2012, in a 20-hours surgical procedure, a digitally planned facial composite tissue allotransplantation was performed consisting of a large amount of bone together with the soft tissue of the entire lower two-thirds of the face. Speech intelligibility, voice, resonance, articulation, and oromyofunctional behavior were measured 12 months after the transplantation using objective and subjective assessment techniques.
Results: No intraoperative surgical complications occurred, and the postoperative course was uneventful. Survival of the graft was complete, the bony structures-both maxillae and part of the left mandible-and mucosal lining of the nasal cavities and hard palate could all be vascularized by connecting only the facial vessels. Twelve months after transplantation, the speech intelligibility is normal in words, but slightly impaired in sentences due to moderate hypernasality. Two articulation disorders and lip incompetence are present. Facial emotional readability was present but decreased.
Conclusion: Speech outcome, as one of several determinants of feasibility, can be a positive argument when considering the option of facial allotransplantation.
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http://dx.doi.org/10.1002/lary.24585 | DOI Listing |
Neurosurg Rev
January 2025
Department of Neurosurgery, IRCCS Neuromed, Via Atinense 18, Pozzilli, IS, 86077, Italy.
Microvascular decompression is considered a first-line treatment in classical trigeminal neuralgia. Teflon is the material commonly used. The use of autologous muscle has been occasionally reported.
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Dermatological Centre in Milan, Milan, Italy.
Acne and acne sequelae can have an important impact on patients' quality of life, affecting interpersonal relationships and social functioning. Acne-induced scars (AIS) and acne-induced macular hyperpigmentation (AIH), in particular, are a major concern for patients with acne, as their management is challenging and often unsatisfactory. Retinoids are considered the mainstay of acne treatment because of their action on multiple pathogenetic factors, and there is increasing evidence that they can also improve AIS and AIH.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Dermatology, University of Texas Medical Branch, 301 University Boulevard, 4.112, McCullough Building, Galveston, TX, 77555, USA.
Keratinocyte carcinomas (KCs) are commonly located on the scalp and often treated with excision with peripheral and deep en face margin assessment (PDEMA), with Mohs micrographic surgery (MMS) being the most frequently used method. Resection of these malignancies results in wounds with a wide variety of sizes, ranging from small, sub-centimeter defects, to extensive, nearly complete scalp defects. MMS is often the preferred treatment for tumor resection and margin clearance, as it allows for maximal healthy tissue preservation and has the lowest recurrence rates.
View Article and Find Full Text PDFJAGN1 (Jagunal-homolog1) is a ER-resident transmembrane protein which is part of the early secretory pathway and granulocyte colony-stimulating factor receptor mediated signaling. Autosomal recessively inherited variants in the JAGN1 gene lead to congenital neutropenia, early-onset bacterial infections, aphthosis and skin abscesses due to aberrant differentiation and maturation of neutrophils. In addition, bone metabolism disorders and a syndromic phenotype, including facial features, short stature and neurodevelopmental delay, have been reported in affected patients.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Oral and Maxillofacial Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Background And Objectives: For the planning of surgical procedures involving the bony reconstruction of the mandible, the autologous iliac crest graft, along with the fibula graft, has become established as a preferred donor region. While computer-assisted planning methods are increasingly gaining importance, the necessary preparation of geometric data based on CT imaging remains largely a manual process. The aim of this work was to develop and test a method for the automated segmentation of the iliac crest for subsequent reconstruction planning.
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