Bone
Research Center of Integrative Cellulomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea; Functional Genomics, School of Engineering, University of Science and Technology (UST), Daejeon 305-806, Republic of Korea. Electronic address:
Published: April 2014
Small heterodimer partner interacting leucine zipper protein (SMILE) is an orphan nuclear receptor and a member of the bZIP family of proteins. Several recent studies have suggested that SMILE is a novel co-repressor that is involved in nuclear receptor signaling; however, the role of SMILE in osteoblast differentiation has not yet been elucidated. This study demonstrates that SMILE inhibits osteoblast differentiation by regulating the activity of Runt-related transcription factor-2 (RUNX2). Tunicamycin, an inducer of endoplasmic reticulum stress, stimulated SMILE expression. Bone morphogenetic protein-2-induced expression of alkaline phosphatase and osteocalcin, both of which are osteogenic genes, was suppressed by SMILE. The molecular mechanism by which SMILE affects osteocalcin expression was also determined. An immunoprecipitation assay revealed a physical interaction between SMILE and RUNX2 that significantly impaired the RUNX2-dependent activation of the osteocalcin gene. A ChIP assay revealed that SMILE repressed the ability of RUNX2 to bind to the osteocalcin gene promoter. Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2.
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http://dx.doi.org/10.1016/j.bone.2013.12.028 | DOI Listing |
Case Rep Dent
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Department of Orthodontics, School of Dentistry, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Class III malocclusion remains the most challenging occlusal problem to treat due to the complexity of the interrelationships of the underlying skeletal and dental structures. Camouflage orthodontic treatment is a preferred alternative method used to manage mild to moderate Class III malocclusion in nongrowing patients. The aim of this article was to demonstrate a camouflage orthodontic treatment of a 22-year-old female patient diagnosed as having a severe skeletal Class III malocclusion characterized by a straight facial profile, reverse overjet, crowded maxillary incisors, retrognathic maxilla, prognathic mandible, and a hypodivergent facial pattern.
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Light Dental Studios, Puyallup, WA 98371, USA.
The aim of the study is to describe the severity, temporal characteristics, and types of autonomic features as they relate to the characteristics of pain of the neuralgias. Also, to describe, based on literature, how these autonomic features can affect the treatment outcomes of patients with craniofacial neuralgias. We carried out a literature search using five databases, PubMed, Embase, OVID, Scopus and Web of Science.
View Article and Find Full Text PDFClin Dermatol
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Agnes Irwin School. Rosemont, Pennsylvania, USA.
The smile is a complex human facial expression, most commonly associated with joy. We present a detailed view on Leonardo Da Vinci's painting of Saint John the Baptist, between 1516 to 1516, which illustrates a smiling saint, which has evoked multiple explanations and theories. Discussing Da Vinci's concept of painting as science media and the two merely contradictory painting techniques chiaroscuro and sfumato, we attempt to approach this picture.
View Article and Find Full Text PDFJ Clin Orthod
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Private Practice of Orthodontics, Face Smile Center, Moscow, Russia.
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