AI Article Synopsis
- X-ray micro computer tomography (μCT) is commonly used to examine bone microarchitecture, but traditional methods face challenges like beam hardening artifacts and limited resolution.
- When paired with synchrotron sources (SRμCT), images can achieve much higher spatial resolution, down to one-tenth of a micrometer.
- SRμCT is regarded as the gold standard for 3D imaging of trabecular bone microarchitecture, effectively visualizing fine details like osteon boundaries and structural differences within mineralized tissue, though it is primarily used for in vitro studies.
Article Abstract
Today X-ray micro computer tomography (μCT) imaging is used to investigate bone microarchitecture. μCT imaging is obtained by polychromatic X-ray beams, resulting in images with beam hardening artifacts, resolution levels at 10 μm, geometrical blurring, and lack of contrasts. When μCT is coupled to synchrotron sources (SRμCT) a spatial resolution up to one tenth of a μm may be achieved. A review of the literature concerning SRμCT was performed to investigate its usability and its strength in visualizing fine bone structures, vessels, and microarchitecture of bone. Although mainly limited to in vitro examinations, SRμCT is considered as a gold standard to image trabecular bone microarchitecture since it is possible in a 3D manner to visualize fine structural elements within mineralized tissue such as osteon boundaries, rods and plates structures, cement lines, and differences in mineralization.
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| http://dx.doi.org/10.1016/j.jcms.2013.11.015 | DOI Listing |
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