AI Article Synopsis
- Three new azaphilones, mycoleptones A, B, and C, were discovered in the fungus Mycoleptodiscus indicus, which is linked to the medicinal plant Borreria verticillata.
- Four known polyketides, austdiol, eugenitin, 6-methoxyeugenin, and 9-hydroxyeugenin, were also extracted from the cultures.
- Various advanced techniques such as NMR, mass spectrometry, and X-ray crystallography were used to analyze the compounds, which showed weak activity against leishmaniasis and low cytotoxicity in tests.
Article Abstract
Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays.
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| http://dx.doi.org/10.1021/np4006822 | DOI Listing |
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