Objective: To describe a reproducible technique for intrastromal injection in the standing horse for treatment of corneal stromal abscessation.
Animal Studied: A retrospective clinical study addressing the history, treatment, and outcome of six equids (six eyes) that received intrastromal voriconazole injection.
Procedure: Equids having a deep stromal abscess suspected to be of fungal origin were administered intrastromal injection of 5% voriconazole solution under standing sedation in an effort to bring about enhanced resolution of clinical disease.
Results: Intracorneal administration of 5% voriconazole solution resulted in resolution of clinical disease, specifically stromal abscessation and secondary uveitis. All animals displayed decreased blepharospasm and no significant complications in the immediate postinjection period. Convalescent periods were subjectively shorter than anticipated with traditional medical therapy. All animals developed mild to moderate stromal fibrosis relative to the initial severity and depth of abscessation.
Conclusions: Intrastromal injection of 5% voriconazole solution may provide a safe and effective treatment option for corneal stromal abscessation in horses. In all reported cases, administration of injection early in the treatment period appeared to contribute to rapid resolution of clinical disease without significant complications. The authors present this technique as an alternative to traditional surgical intervention, being more economical, having shorter treatment duration, and potentially resulting in less scar formation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/vop.12136 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advantages of the refined Developability Classification System (rDCS) in early discovery.
J Pharm Sci
December 2024
Janssen Research & Development, LLC, Discovery Pharmaceutics, San Diego, CA, USA.
Rat pharmacokinetic studies are commonly utilized in early discovery to support absorption, distribution, metabolism, and excretion optimization of active pharmaceutical ingredients (APIs). The aim of this work was to compare exposures from fit-for-purpose oral suspension and solution formulations in rats to guidance provided by the refined Developability Classification System (rDCS) with respect to identifying potential limits to oral absorption, formulation strategy selection, and to optimize oral bioavailability (BA). This investigation utilized six diverse APIs covering a large range of biorelevant solubility, metabolic stability, and oral BA in rats.
View Article and Find Full Text PDFEvaluation of topical 1% posaconazole therapy in refractory fungal keratitis.
Indian J Ophthalmol
January 2025
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Purpose: The primary objective was to evaluate the clinical response of refractory cases of fungal keratitis to topical 1% posaconazole therapy.
Methods: Prospective longitudinal non-randomized open label dual-cohort study of 70 eyes of refractory fungal keratitis, 35 were recruited as posaconazole treatment (PCZ) group for topical 1% posaconazole therapy and compared to 35 eyes on conventional antifungal therapy. Study parameters included demographic and treatment details, visual acuity, comprehensive slit-lamp biomicroscopy, clinical photography, ASOCT at recruitment and weekly (week 1, 2, 3 and 4 after treatment initiation).
Enhanced Oral Bioavailability and Biodistribution of Voriconazole through Zein-Pectin-Hyaluronic Acid Nanoparticles.
ACS Appl Mater Interfaces
January 2025
Laboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste-UNICENTRO, Alameda Élio Antônio Dalla Vecchia, 838, 85040-167 Guarapuava, PR, Brazil.
Nanotechnology-based drug delivery systems offer a solution to the pharmacokinetic limitations of voriconazole (VRC), including saturable metabolism and low oral bioavailability. This study developed zein/pectin/hyaluronic acid nanoparticles (ZPHA-VRC NPs) to improve VRC's pharmacokinetics and biodistribution. The nanoparticles had a spherical morphology with an average diameter of 268 nm, a zeta potential of -48.
View Article and Find Full Text PDFStandardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformans.
Sci Rep
October 2024
Community for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Article Synopsis
- The CLSI M27 guidelines are the standard protocols for testing yeast antifungal susceptibility using 96-well plates, but this setup limits the number of antifungal compounds that can be tested simultaneously.
- With the rise of fungal resistance, there's a need for alternative methods that allow for higher throughput screening of more antifungal drugs.
- This study introduces an optimized microdilution method using 384-well plates, which improves efficiency and consistency while validating the process with ten commonly used antifungals against specific yeast species.
In Vivo Confocal Microscopy Findings of a Rare Keratitis.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Purpose: To report a rare case of fungal keratitis caused by , highlighting its unique morphological features using in vivo confocal microscopy (IVCM).
Methods: This was a retrospective case report. A 66-year-old man presented with foreign body sensation and blurred vision in his left eye for over 10 months.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!