Epigenetic traces of childhood maltreatment in peripheral blood: a new strategy to explore gene-environment interactions.

Br J Psychiatry

Rudolf Uher, MD, PhD, MRCPsych, Dalhousie University Department of Psychiatry, Halifax, Nova Scotia, Canada, and Institute of Psychiatry, King's College London, UK; Ian C. G. Weaver, PhD, Dalhousie University Department of Psychology & Neuroscience, Department of Psychiatry and the Brain Repair Centre, Halifax, Nova Scotia, Canada.

Published: January 2014

Maltreatment in childhood affects mental health over the life course. New research shows that early life experiences alter the genome in a way that can be measured in peripheral blood samples decades later. These findings suggest a new strategy for exploring gene-environment interactions and open opportunities for translational epigenomic research.

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Source
http://dx.doi.org/10.1192/bjp.bp.113.127209DOI Listing

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