AI Article Synopsis
- Researchers analyzed gene expression in 1,707 cancer samples across six types: breast, ovarian, brain, colorectal, lung adenocarcinoma, and squamous cell lung cancer.
- They discovered that Basal-like breast tumors are distinct from other breast cancers, sharing more similarities with squamous cell lung cancers.
- The findings indicate that clinical trials should target tumors with similar molecular profiles, especially focusing on Basal-like breast cancer and squamous cell lung carcinoma, rather than solely considering their tissue of origin.
Article Abstract
To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506566 | PMC |
| http://dx.doi.org/10.1038/srep03544 | DOI Listing |
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