AI Article Synopsis
- Scientists studied how using a special liquid from fat cells (ADSC-CM) can help heal skin wounds better after a specific laser treatment (FxCR).
- They treated 19 people and compared one arm that got the special liquid to the other arm that didn’t.
- Results showed that the arm with the special liquid healed faster and had less redness, dark spots, and water loss than the control arm.
Article Abstract
Objective: To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin.
Materials And Methods: Nineteen subjects were treated with FxCR on the bilateral inner arms. ADSC-CM was applied on FxCR site of one randomly selected arm. Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured. Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted.
Results: The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side. The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group.
Conclusion: Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867954 | PMC |
| http://dx.doi.org/10.1155/2013/519126 | DOI Listing |
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