Background: High prevalence of vitamin D deficiency (VDD) has been reported throughout the India for all age groups. Increased awareness about VDD among treating physicians has led to increased prescriptions of vitamin D preparations. Based on our experience of varied clinical and radiological response with different vitamin D formulations, we decided to assess cholecalciferol content of commonly available vitamin D formulations.
Materials And Methods: We measured cholecalciferol content of 14 commercial preparations (two in the form of tablets and 12 as sachet) available in Indian market. Lab analysis was carried out in Shriram Institute for Industrial Research by high-performance liquid chromatography.
Results: Of the total 14 samples analyzed only 4 (28.57%) were found to be within the acceptable ranges from -90 to +125% as defined by Indian Pharmacopia while 5 (35.7%) had higher and 5 (35.7%) had lower than the acceptable range. The percentage variation in cholecalciferol content as observed from the printed ranged widely from -91% to +65%.
Conclusions: Our study shows a high degree of variability in cholecalciferol content of commercial preparations available in the Indian pharmaceutical market. This variation has many clinical implications as it may lead both, under treatment as well as vitamin D toxicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872693 | PMC |
| http://dx.doi.org/10.4103/2230-8210.122638 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CCAAT/Enhancer-Binding Protein β (C/EBPβ) Regulates Calcium Deposition in Smooth Muscle Cells.
Int J Mol Sci
December 2024
Department of Pharmacology, Chonnam National University Medical School, Hwasun 58128, Republic of Korea.
Calcium deposition in vascular smooth muscle cells (VSMCs), a form of ectopic ossification in blood vessels, can result in rigidity of the vasculature and an increase in cardiac events. Here, we report that CCAAT/enhancer-binding protein beta (C/EBPβ) potentiates calcium deposition in VSMCs and mouse aorta induced by inorganic phosphate (Pi) or vitamin D. Based on cDNA microarray and RNA sequencing data of Pi-treated rat VSMCs, C/EBPβ was found to be upregulated and thus selected for further evaluation.
View Article and Find Full Text PDFThe Potential of an Artificially Ultraviolet B Irradiated Hay as a Source of Vitamin D.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Article Synopsis
- Roughage in herbivore diets can be an important source of vitamin D, with levels varying based on factors like plant species, maturity, and UVB exposure.
- UVB light promotes the conversion of provitamin D to vitamin D, which significantly impacts vitamin D content in forages.
- In a study, ergocalciferol levels in roughage increased significantly with UVB exposure, highlighting the potential of hay as a valuable vitamin D source for herbivores and emphasizing the need to consider UVB's effects in both practical and research contexts.
Effect of Different Dietary Doses of Black Soldier Fly Meal on Performance and Egg Quality in Free-Range Reared Laying Hens.
Animals (Basel)
November 2024
Granja Monte Encinar, El Barraco, 05110 Ávila, Spain.
(1) Background: Given the problems currently posed by the use of soybean meal in poultry feeding, its replacement with black soldier fly (BSF) meal may be a suitable strategy. Therefore, this study evaluated the effect of this dietary replacement on laying performance, egg quality, and yolk nutritional composition in free-range reared hens. (2) Methods: Three diets were formulated: a control diet with 210 g/kg of soybean meal, a diet with 105 g/kg of soybean meal and 80 g/kg of BSF meal, and a diet with 160 g/kg of BSF meal.
View Article and Find Full Text PDFVitamin D requirements and relative bioavailability for starter male White Pekin ducks fed either cholecalciferol or 25-hydroxycholecalciferol.
Poult Sci
November 2024
State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. Electronic address:
The objectives were to investigate effects of various concentrations of dietary vitamin D (VD) or 25-hydroxycholecalciferol (25-OH-D) on growth performance, VD status, calcium (Ca) metabolism, and tibia mineralization of starter male White Pekin ducks, and dietary requirements and relative bioavailability of these two compounds. One-day-old male White Pekin ducks (n = 624) were assigned to 13 dietary treatments, including 6 added VD concentrations (100, 200, 400, 800, 1200, and 2000 IU/kg), and 2 vitamin D sources (VD and 25-OH-D), plus a negative control (no vitamin D supplementation) for 21 days. Each group had 6 replicate pens of 8 birds per pen.
View Article and Find Full Text PDFEffects of High-Dose Vitamin D3 Supplementation on Pig Performance, Vitamin D Content in Meat, and Muscle Transcriptome in Pigs.
J Anim Physiol Anim Nutr (Berl)
November 2024
Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, Krakowska, Poland.
Vitamin D is known for its role in calcium homeostasis, bone health, and immune function. Recent research has explored its effects on muscle functionality and meat quality in pigs. This study examined high-dose vitamin D3 supplementation in pigs, focusing on growth, blood and tissue vitamin D3 levels, and muscle transcriptome changes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!