Methotrexate is an effective anticancer and immunosuppressive agent. However, nephrotoxicity is one of the complications of its use. On the other hand, curcumin, a naturally occurring polyphenolic compound, is reported to have antioxidant and anti-inflammatory properties. Those two properties are likely to prevent methotrexate-induced nephrotoxicity. The aim of this study is to evaluate the possible protective effect of curcumin against methotrexate-induced nephrotoxicity and delineate various mechanism(s) underlies this effect in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of methotrexate (7 mg/kg/day) for three consecutive days. Curcumin administration in methotrexate-intoxicated rats resulted in nephroprotective effects as evidenced by the significant decrease in levels of serum creatinine and urea as well as renal malondialdehyde, nitric oxide, and tumor necrosis factor- α with a concurrent increase in renal glutathione peroxidase and superoxide dismutase activities compared to nephrotoxic untreated rats. Additionally, immunohistochemical analysis demonstrated that curcumin treatment markedly reduced cyclooxygenase-2 expression. Histopathological examination confirmed the protective effects of curcumin. In conclusion, curcumin protected rats from methotrexate nephrotoxicity, at least in part, through its antioxidant and anti-inflammatory activities.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870078 | PMC |
| http://dx.doi.org/10.1155/2013/387071 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Standard Versus Reduced Hydration to Improve Elimination of High-Dose Methotrexate in Pediatric Patients: A Controlled Crossover Trial.
Pediatr Blood Cancer
January 2025
Department of Pediatrics, Children's Hospital of Richmond at VCU Health, Richmond, Virginia, USA.
Background: Hydration and urine alkalinization are the mainstays for the prevention of methotrexate-induced nephrotoxicity. Current oncology protocols recommend pediatric patients who are administered high-dose methotrexate (HDMTX) to be aggressively hydrated with an alkaline solution, which may lead to overhydration. This pilot study sought to determine whether reduced posthydration results in a shorter time to methotrexate elimination without increasing adverse effects.
View Article and Find Full Text PDFNephroprotective Potential of 1,3,4-Oxadiazole Derivative Against Methotrexate-Induced Nephrotoxicity in Rats by Upregulating Nrf2 and Downregulating NF-κB and TNF-α Signaling Pathways.
J Biochem Mol Toxicol
December 2024
Department of Pharmacy,Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Nephrotoxicity is a prominent complication of methotrexate (MTX) therapy that limits clinicians in its extensive use. MTX triggers oxidative burden and inflammation, so the nephroprotective potential of the synthetic derivative of 1,3,4-oxadiazole (5b) was explored in this research. Male Wistar rats were divided into four groups i.
View Article and Find Full Text PDFAssessment of morin hydrate as a renal protective agent in rats subjected to methotrexate-induced nephrotoxicity.
Drug Chem Toxicol
November 2024
Department of Medical Biochemistry, Bilecik Seyh Edebali University, Bilecik, Turkey.
Methotrexate (MTX) is a generally applied chemotherapeutic medicine in most cancers treatment. Morin hydrate, a robust antioxidant, is a secondary metabolite observed in numerous plants, along with figs, white mulberries, and others. The hypothesis of this study is that morin hydrate can effectively reduce MTX-induced kidney injury in rats by increasing antioxidant enzyme activity and inhibiting apoptotic processes.
View Article and Find Full Text PDFSumac liposomes/mesenchymal stem cells fight methotrexate-induced nephrotoxicity in rats via regulating Nrf-2/Keap-1/HO-1 and apoptotic signaling pathways.
Arch Pharm (Weinheim)
January 2025
Deraya Center for Scientific Research, Deraya University, New Minia, Egypt.
Methotrexate (MTX) is commonly employed in cancer treatment, but its clinical use is restricted due to the MTX-associated renal injury. This study investigates the combined potential of Rhus coriaria (sumac) and bone marrow mesenchymal stem cells (BMMSCs) against MTX-induced nephrotoxicity in rats. The high-resolution-liquid chromatography-mass spectrometry (HR-LC-MS) of sumac extract tentatively identified 22 phytochemicals, mostly flavonoids, anthocyanins, and steroids.
View Article and Find Full Text PDFRole of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment.
Toxicol Rep
December 2024
Facultad de Químico-Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
Article Synopsis
- Methotrexate (MTX) is commonly used for treating psoriasis but can cause kidney damage, which antioxidants like vitamin C (vitC) might mitigate.
- A study using a mouse model of psoriasis explored how vitC impacts kidney toxicity from high doses of MTX, finding that while vitC can reduce kidney damage, it may worsen skin lesions and kidney injury when combined with IMQ (a psoriasis-inducing agent).
- The findings indicate that vitC could be beneficial for renal protection in psoriasis but should not be used alongside MTX in patients with existing kidney issues.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!