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Generic antiretroviral drugs in developing countries: friends or foes? | LitMetric

Generic antiretroviral drugs in developing countries: friends or foes?

AIDS

aHôpital FOCH, Suresnes, France bFrance Expertise Internationale, Paris, France cPharmaco-Toxicology Department, Hôpital Bichat, Paris, France.

Published: February 2014

AI Article Synopsis

Article Abstract

Although second-line generic antiretroviral drugs are of great value in developing countries, there are concerns regarding their quality. We studied a generic Lopinavir/ritonavir (200/50  mg; Arga-L, India) marketed in the Republic of Congo but not prequalified by WHO. Despite adequate quantitative and qualitative drug content, Arga-L had a bio-availablility of 10% compared with Kaletra. To avoid selection of drug-resistant HIV, rigorous pharmacological monitoring of generic drugs not prequalified by WHO must be a priority.

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Source
http://dx.doi.org/10.1097/QAD.0000000000000170DOI Listing

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