AI Article Synopsis
- Cold knife conization is a surgical procedure used to diagnose and treat high-grade cervical lesions (CIN), and this study focused on the outcomes of cases without CIN after undergoing the procedure for prior lesions.
- A retrospective analysis was conducted on 173 women who had the conization, comparing those who had no CIN (Group 1) to those with residual CIN (Group 2) over one year post-surgery.
- Results showed no significant differences in demographics, HPV status, or recurrence rates between the two groups, suggesting similar follow-up care for both types of cases post-conization.
Article Abstract
Background: Cold knife conization is a surgical procedure that allows both diagnosis and treatment of cervical lesions at the same time. It is mainly performed for indications of high-grade cervical intraepithelial neoplasia (CIN). In this study, we aimed to investigate the clinical outcome of cases without CIN in cold knife conization specimen, following a high-grade lesion (CIN2/3) in cervical biopsy.
Materials And Methods: We performed a retrospective cohort study at a tertiary referral hospital between January 1st 2008 and August 1st 2012. Cases that underwent cold knife conization for CIN2/3 within the study period were included. Cone-negative (Group 1) and cone-positive (Group 2) cases were analyzed for various clinical parameters, and were compared in the 1-year post-conization period for histological recurrence and human papillomavirus (HPV) DNA status.
Results: A total of 173 women underwent cold knife conization for CIN2/3 within the study period. Twenty-two cases (12.7%) were included in Group 1 and 151 cases (87.3%) in Group 2. There were no significant differences between the two groups in terms of age, gravidity, parity, menopausal status and HPV-DNA status (pre-conization and 1 year post-conization) (p>0.05). Recurrence rates were also similar between the groups (9.1% vs 9.9%, p>0.05).
Conclusions: Clinical outcomes were similar in terms of histological recurrence and HPV persistence after 1 year of follow-up between cone-negative and cone-positive cases. Clinical follow-up of cone-negative cases should therefore be performed similar to cone-positive cases.
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| http://dx.doi.org/10.7314/apjcp.2013.14.11.6693 | DOI Listing |
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