AI Article Synopsis
- Cerebral aneurysms are significant health concerns due to their risk of rupture, and current management strategies include monitoring and surgical interventions like clipping and coiling, which carry risks.
- Recent research has highlighted that inflammation is a key factor in the development and rupture of these aneurysms.
- The review aims to explore the causes of cerebral aneurysms and the potential for new drugs that reduce inflammation in the aneurysm wall, which might lower the chances of rupture.
Article Abstract
The formation of cerebral aneurysms and their rupture propensity is of immediate clinical importance. Current management includes observation with expectant management, microsurgical clipping and/or endovascular coiling. The surgical options are invasive and are not without increased risk despite the technological advances. Recent human and animal studies have shown that inflammation plays a critical role in aneurysm formation and progression to rupture. Modulating this inflammatory process may prove to be clinically significant. This review will discuss cerebral aneurysm pathogenesis with a focus on current and future research of potential use of pharmaceutical agents that attenuate inflammation in the aneurysm wall leading to decreased risk of aneurysm rupture.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873146 | PMC |
| http://dx.doi.org/10.2217/fnl.13.40 | DOI Listing |
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