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Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics. | LitMetric

Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.

Adv Healthc Mater

Institute for Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

Published: June 2014

AI Article Synopsis

Article Abstract

This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053479PMC
http://dx.doi.org/10.1002/adhm.201300521DOI Listing

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