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Putting advanced materials to the test: TiC MXenes alleviate the hazardous effects of the environmental pollutant benzo[a]pyrene.
Chemosphere
October 2024
Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden. Electronic address:
Advanced materials are materials that have been engineered to exhibit novel or enhanced properties that confer superior performance when compared to conventional materials. Here, we evaluated the impact of TiC MXenes, a two-dimensional (2D) material, on the adverse effects caused by polycyclic aromatic hydrocarbons. To this end, we studied benzo[a]pyrene denoted here as B[a]P as a model compound.
View Article and Find Full Text PDFIs foramen magnum decompression for acquired Chiari I malformation like putting a finger in the dyke? - A simplistic overview of artificial intelligence in assessing critical upstream and downstream etiologies.
J Craniovertebr Junction Spine
May 2024
Department of Neurosurgery, Insight Institute of Neurosurgery and Neuroscience, Flint, MI, USA.
Article Synopsis
- The text discusses the challenges in diagnosing idiopathic intracranial hypertension (IIH) and spontaneous intracranial hypotension (SIH), which can cause ongoing symptoms after Chiari malformation (CM) I surgery, and introduces the use of artificial intelligence (AI) to aid in this diagnosis through a new workflow called MaChiP 1.0.
- It emphasizes the importance of utilizing both upstream and downstream MRI findings to better identify and categorize Chiari malformation subtypes and related conditions, particularly utilizing upright imaging for better assessment.
- The authors outline a systematic review of relevant literature on machine learning in Chiari I malformation and propose specific MRI criteria to help differentiate between primary and secondary causes of the condition for improved diagnosis
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers.
Cancer Cell
May 2024
Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:
TP53-mutant blood cancers remain a clinical challenge. BH3-mimetic drugs inhibit BCL-2 pro-survival proteins, inducing cancer cell apoptosis. Despite acting downstream of p53, functional p53 is required for maximal cancer cell killing by BH3-mimetics through an unknown mechanism.
View Article and Find Full Text PDFOnline trend estimation and detection of trend deviations in sub-sewershed time series of SARS-CoV-2 RNA measured in wastewater.
Sci Rep
March 2024
Houston Health Department and Department of Statistics, Rice University, 6100 Main St., Houston, TX, 77005, USA.
Wastewater surveillance has proven a cost-effective key public health tool to understand a wide range of community health diseases and has been a strong source of information on community levels and spread for health departments throughout the SARS- CoV-2 pandemic. Studies spanning the globe demonstrate the strong association between virus levels observed in wastewater and quality clinical case information of the population served by the sewershed. Few of these studies incorporate the temporal dependence present in sampling over time, which can lead to estimation issues which in turn impact conclusions.
View Article and Find Full Text PDFPutting everything in its place: using the INSDC compliant Pathogen Data Object Model to better structure genomic data submitted for public health applications.
Microb Genom
December 2023
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Fast, efficient public health actions require well-organized and coordinated systems that can supply timely and accurate knowledge. Public databases of pathogen genomic data, such as the International Nucleotide Sequence Database Collaboration (INSDC), have become essential tools for efficient public health decisions. However, these international resources began primarily for academic purposes, rather than for surveillance or interventions.
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