AI Article Synopsis
- Phosphatidylinositol 5-phosphate (PtdIns5P) is a special type of fat found in cells that helps control how they work, even though scientists don't know as much about it compared to other similar fats.
- It's found in small amounts in places like the cell's outer layer, inside the cell, and in the nucleus, and its levels change when cells face challenges or diseases.
- Recent research has shown that different enzymes help make and manage PtdIns5P, and it plays a big role in how cells move, change shape, and even how they read and respond to their DNA.
Article Abstract
Phosphatidylinositol 5-phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, and type II PtdInsP-kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner.
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| http://dx.doi.org/10.1002/bies.201300132 | DOI Listing |
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