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A Phase I, First-In-Human Study of CBA-1205, an Anti-DLK1 Monoclonal Antibody, in Patients With Advanced Solid Tumors.
Cancer Sci
January 2025
Department of Experimental Therapeutics, National Cancer Center Hospital, Chuo-ku, Japan.
CBA-1205 is a novel humanized antibody targeting delta-like 1 homolog (DLK1) that enhances antibody-dependent cellular cytotoxicity activity. DLK1 overexpression has been reported in various cancer types, such as hepatocellular carcinoma and neuroblastoma. CBA-1205 demonstrates potent antitumor activity in multiple tumor models, making it a potential treatment option for DLK1-expressing cancers.
View Article and Find Full Text PDF[Video-assisted thoracic surgery-Indications, importance and technique].
Chirurgie (Heidelb)
January 2025
Klinik und Poliklinik für Chirurgie, Sektion Thoraxchirurgie, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.
Video-assisted thoracic surgery (VATS) is a safe and effective surgical procedure. Completely minimally invasive operations must be distinguished from hybrid procedures. The VATS can be used for diagnostic and treatment purposes for all oncological and non-oncological diseases of the thoracic organs.
View Article and Find Full Text PDFPhoenix Comprehensive Assessment of Pectus Excavatum Symptoms (PCAPES).
J Thorac Dis
December 2024
Department of Cardiovascular and Thoracic Surgery, Mayo Clinic, Phoenix, AZ, USA.
Background: Pectus excavatum (PE) can cause cardiopulmonary compression with a wide range of symptoms and psychosocial effects. Few validated surveys assess the extensive symptomatology of the adult pectus population. A comprehensive symptom survey was developed and validated with outcomes presented.
View Article and Find Full Text PDFWhat do patients know about their newly prescribed medication: Application of a novel knowledge index.
Patient Educ Couns
January 2025
Institute for Integrative Health Care and Health Promotion (IGVF), Witten/Herdecke University, Witten, Germany.
Objective: The present study aimed to evaluate patients' knowledge about their newly prescribed medications, contributing factors, and preferred sources of medication-related information.
Methods: A cross-sectional study using an online survey was conducted among 931 customers of a mail-order pharmacy. Medication-related knowledge was examined using a novel knowledge index (KI) assessing medication dosage, indication, time of administration, and side effects.
TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity.
NPJ Vaccines
January 2025
Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
In situ vaccination (ISV) triggers antitumor immune responses using the patient's own cancer antigens, yet limited neoantigen release hampers its efficacy. Our novel combination therapy involves low-dose local cisplatin followed by ISV with a TLR7/8/9 agonist formulation (CR108), in which CR108 boosts and sustains the antitumor responses induced by the cisplatin-released neoantigens. In mouse models, the cisplatin+CR108 combination significantly outperformed cisplatin or CR108 alone in abrogating established 4T1 and B16 tumors.
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