Truncated norzoanthamine exhibiting similar collagen protection activity, toward a promising anti-osteoporotic drug.

Bioorg Med Chem Lett

Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Published: January 2014

The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. Due to its rarity and complicated structure, a practical supply method must be developed. Here, we designed a truncated norzoanthamine, which has two-thirds of the original structure, and found that it exhibited similar collagen protection activity.

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Source
http://dx.doi.org/10.1016/j.bmcl.2013.12.032DOI Listing

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