A 70 year old female patient presented with complaints of pain, watering and swelling in the right eye. She gave a history of fall, as she was walking in the paddy field of her farm. Ophthalmological and Microbiological investigation revealed a fungal keratitis with an unusual fungus Macrophomina phaseolina which is primarily a plant pathogen, with a potential to cause human infections especially in immuno-compromised patients. The patient responded well to the antifungal treatment with Oral Voriconazole with absence of recurrence and dissemination.
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http://dx.doi.org/10.1016/j.mmcr.2012.10.007 | DOI Listing |
Invest Ophthalmol Vis Sci
March 2025
Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China.
Purpose: Fungal keratitis (FK) is a challenging and sight-threatening corneal disease caused by fungal infections. Although long noncoding RNAs (lncRNAs) have been explored in various infectious diseases, their specific roles in FK remain largely unexplored.
Methods: A mouse model of FK was created by infecting corneal stromal cells with Fusarium solani.
Infect Drug Resist
March 2025
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China.
Background: Fungal keratitis is relatively rare in children. This study aimed to analyze the clinical characteristics and treatment outcomes of pediatric fungal keratitis.
Methods: A retrospective review of medical records was conducted for children (aged <18 years) diagnosed with fungal keratitis from 1996 to 2021.
Exp Eye Res
March 2025
Instituto Universitario Fernández-Vega (IUFV), Fundación de Investigación Oftalmológica, University of Oviedo, 33012, Oviedo, Spain; Department of Functional Biology, University of Oviedo, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain. Electronic address:
The yeast form of Candida albicans uses glycosaminoglycans (GAGs), primarily heparan sulfate, as adhesion receptors for corneal epithelial cells. However, during the transition to the hyphal form, the fungus shifts to using alternative receptors. This study aims to identify fungal adhesins involved in GAG binding and examine their expression dynamics during tissue adhesion.
View Article and Find Full Text PDFExp Eye Res
March 2025
Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China. Electronic address:
Fungal keratitis (FK) is a severe vision-threatening eye disease. The fungal invasiveness and excessive inflammatory response contribute to corneal tissue damage. Rutin (RT) possesses anti-inflammatory, antimicrobial, antioxidant, and improved wound-healing characteristics.
View Article and Find Full Text PDFInt J Parasitol Drugs Drug Resist
February 2025
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; Department of Parasitology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address:
This review examines the advancements in antimicrobial drug discovery with in vitro assays for Acanthamoeba, highlighting the efficacy of current topical antimicrobial agents. In recent decades, the treatment and diagnosis of Acanthamoeba keratitis (AK) have presented clinical challenges. Clinicians often rely on clinical judgment, risk factors, and patient travel history to guide initial treatment decisions.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!