Cross-reactivity of Aspergillus galactomannan in an HIV-infected patient with histoplasmosis.

Med Mycol Case Rep

Division of Infectious Diseases, Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, N555, Baltimore, MD 21201, USA.

Published: December 2013

Non-invasive assays are increasingly being used in patients with suspected fungal infections. Limitations to these tests include limited sensitivity, specificity, and cross reactivity with other fungal pathogens. Herein we report a case of disseminated histoplasmosis producing a false positive serum and bronchoalveolar lavage (BAL) Aspergillus galactomannan assays. This test may have a role in the evaluation of patients with suspected histoplasmosis in settings where Histoplasma antigen testing is not widely available.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854635PMC
http://dx.doi.org/10.1016/j.mmcr.2012.10.009DOI Listing

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