Rh(III)-catalyzed amide-directed cross-dehydrogenative heteroarylation of pyridines.

Org Lett

A State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou, Fujian 350002, China.

Published: January 2014

A new catalytic methodology has been developed for the synthesis of heteroaryled pyridines via a rhodium(III)-catalyzed dehydrogenative cross-coupling reaction. This protocol features a good substrate scope with a broad range of functional group tolerance and high regioselectivity of the pyridyl C-H activation.

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Source
http://dx.doi.org/10.1021/ol403311bDOI Listing

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