Aim. To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS) by optical coherence tomography (OCT). Materials and Method. We studied 43 new diagnosed OSAS patients and 40 healthy volunteers. Patients underwent an overnight sleep study in an effort to diagnose and determine the severity of OSAS. RNFL analyses were performed using Stratus OCT. The average and the four-quadrant RNFL thickness were evaluated. Results. There was no difference between the average and the four-quadrant RNFL thickness in OSAS and control groups. There was no correlation between apnea-hypopnea index and intraocular pressure. Body mass index of patients with moderate and severe OSAS was significantly higher in patients with mild OSAS. Conclusion. Mean RNFL thickness did not differ between the healthy and the OSAS subjects, however, the parameters were more variable, with a larger range in OSAS patients compared to controls.
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http://dx.doi.org/10.1155/2013/292158 | DOI Listing |
Background: Despite an aging population, it remains challenging to reliably differentiate between loss of cognitive function associated with normal aging and cognitive decline associated with pathologic processes. With growing interest in using retinal and optic nerve biomarkers to diagnose neurodegenerative diseases, characterization of the velocity of normal retinal age-related changes will further our understanding. We evaluated longitudinal microvascular changes in cognitively normal older adults using optical coherence tomography (OCT) and OCT angiography (OCTA).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea, Republic of (South).
Background: Spectrum Domain-Optical Coherence Tomography (SD-OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Macular thickness and retinal nerve fiber layer (RNFL) thickness measured by an SD-OCT have been used as a indicator of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However which portion of retinal RNFL is the most sensitive area among normal control, aMCI and AD is not clear yet.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Background: The early detection of preclinical dementia is crucial, prompting investigations into retinal biomarkers using optical coherence tomography (OCT). Inconsistent and limited longitudinal studies have been done to clarify the association between the retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness and cognitive function over time. This study aims to explore the association between retinal biomarkers and cognitive function over time in non-demented older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Alabama at Birmingham, Birmingham, AL, USA.
Background: The potential of plasma Aβ42/Aβ40 ratio, NfL, p-tau 181, and p-tau 217 has been extensively discussed in the literature. Our previous study explored the association between retinal biomarkers and preclinical AD. The goal of this study was to evaluate the association and a multimodal model of retinal and plasma biomarkers for detection of preclinical AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South).
Background: To elucidate the biological mechanisms underpinning the association between macular Retinal Nerve Fiber Layer (RNFL) thickness and cognitive function in older adults, this study investigates its correlation with brain volume and cortical thickness.
Method: From a community-dwelling prospective cohort, we included 166 non-demented participants aged over 65 years (mean age 75.2 ± 5.
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