Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270870 | PMC |
| http://dx.doi.org/10.3390/molecules19010139 | DOI Listing |
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