AI Article Synopsis
- Two series of inhibitors targeting type III phosphatidylinositol-4-kinase were discovered and refined to specifically block the α- and β-isoforms without affecting similar kinases.
- Inhibiting the α-isoform, but not the β-isoform, resulted in lower levels of key molecules (phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate) within cells.
- This reduction led to decreased formation of inositol-1-phosphate and ultimately hindered the growth of various cancer cell lines.
Article Abstract
Two series of inhibitors of type III phosphatidylinositol-4-kinase were identified by high throughput screening and optimised to derive probe compounds that independently and selectively inhibit the α- and the β-isoforms with no significant activity towards related kinases in the pathway. In a cellular environment, inhibition of the α- but not the β-subtype led to a reduction in phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate concentration, causing inhibition of inositol-1-phosphate formation and inhibition of proliferation in a panel of cancer cell lines.
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| http://dx.doi.org/10.1039/c3cc48391f | DOI Listing |
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