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Do microglia metabolize fructose in Alzheimer's disease?
J Neuroinflammation
March 2025
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, Aurora, CO, 80045, USA.
Alzheimer's disease (AD) is an age-associated neurodegenerative disorder with a complex etiology. While emerging AD therapeutics can slow cognitive decline, they may worsen dementia in certain groups of individuals. Therefore, alternative treatments are much needed.
View Article and Find Full Text PDFAdverse childhood experiences and their influence on psychological well-being and emotional intelligence among university students.
BMC Psychol
March 2025
Department of Clinical Neuroscience, College of Medicine, King Faisal University, Alhasa, Saudi Arabia.
Background: Adverse Childhood Experience (ACEs) have been linked to several detrimental health outcomes, including poor mental health. Due to the change from high school to college life and the increasing pressures, university students are especially susceptible to the harmful effects of ACEs. Emotional intelligence (EI) has been identified as a protective factor against the negative impact of ACEs on psychological well-being (PWB).
View Article and Find Full Text PDFIFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation.
J Neuroinflammation
March 2025
Neuroprotective Drug Discovery Key Laboratory, Jiangsu Key Laboratory of Neurodegeneration, State key laboratory of reproductive medicine and offspring health, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Maternal immune activation (MIA) is a principal environmental risk factor contributing to autism spectrum disorder (ASD) and can be causally linked to ASD symptoms. In our study, we found that MIA triggered by poly (I: C) injection caused ventriculomegaly in offspring due to the dysfunction of the choroid plexus (Chp) and ependyma. We subsequently identified a sustained enhancement of interferon-γ (IFN-γ) signaling in the brain and serum of MIA offspring.
View Article and Find Full Text PDFEffects of psychosocial factors on postpartum depression: a half-longitudinal mediation analysis of cognitive reactivity.
BMC Pregnancy Childbirth
March 2025
School of Nursing, Fujian Medical University, No 1 Xueyuan Road, Minhou county, Fuzhou, Fujian, 350122, China.
Background: The prevention and treatment of perinatal depression are currently the focus of perinatal health care, with cognitive reactivity confirmed to be an important predictor. However, how cognitive reactivity mediates the relationship between psychosocial factors (e.g.
View Article and Find Full Text PDFLong-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients.
BMC Geriatr
March 2025
Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No.7. Weiwu Road, Zhengzhou, Henan, China.
Background: Postoperative hyperactive delirium is a common and serious complication in older patients undergoing surgery, but the association between delirium and mortality remains controversial. Compared to other delirium subtypes, hyperactive delirium is characterized by more overt clinical manifestations, facilitating accurate detection and evaluation. This study aimed to clarify this association by comparing long-term mortality between patients with and without postoperative hyperactive delirium, using propensity score matching for robust analysis.
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