Pericardial cysts are rare mediastinal abnormalities occurring in 1 in 100,000 persons. Most pericardial cysts are congenital but may also be acquired. Their presence poses a diagnostic challenge, distinguishing them from other intracardiac and mediastinal lesions. We describe an unusual presentation of a large pericardial cyst which was diagnosed during the evaluation of prolonged fever, abdominal pain and diarrhea. This case emphasizes that the evaluation and treatment of a pericardial cyst should be based on clinical judgment and should be managed on a case by case basis.
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