AI Article Synopsis
- The encoding of odors in the olfactory system occurs through specific combinations of glomeruli, but how these signals are integrated remains unclear.
- In the fruit fly Drosophila melanogaster, the lateral horn neurons receive input from select combinations of glomeruli, with some combinations being more prevalent than others.
- This study reveals two types of lateral horn neurons—one broadly tuned that integrates multiple inputs for a wider response range, and another narrowly tuned that exhibits strong odor-selective inhibition, highlighting their distinct functions in processing innate versus learned behaviors.
Article Abstract
In the first brain relay of the olfactory system, odors are encoded by combinations of glomeruli, but it is not known how glomerular signals are ultimately integrated. In Drosophila melanogaster, the majority of glomerular projections target the lateral horn. Here we show that lateral horn neurons (LHNs) receive input from sparse and stereotyped combinations of glomeruli that are coactivated by odors, and certain combinations of glomeruli are over-represented. One morphological LHN type is broadly tuned and sums input from multiple glomeruli. These neurons have a broader dynamic range than their individual glomerular inputs do. By contrast, a second morphological type is narrowly tuned and receives prominent odor-selective inhibition through both direct and indirect pathways. We show that this wiring scheme confers increased selectivity. The biased stereotyped connectivity of the lateral horn contrasts with the probabilistic wiring of the mushroom body, reflecting the distinct roles of these regions in innate as compared to learned behaviors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992254 | PMC |
| http://dx.doi.org/10.1038/nn.3613 | DOI Listing |
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