AI Article Synopsis
- - The study aimed to meta-analyze the diagnostic accuracy of serum glypican-3 (GPC-3) for diagnosing hepatocellular carcinoma (HCC), given inconsistent results from prior research.
- - Twelve studies involving 898 HCC patients and 835 non-HCC patients showed that GPC-3 has moderate sensitivity (53%) and relatively better specificity (77%) for HCC diagnosis, with an area under the curve (AUC) of 0.82.
- - The authors noted design flaws in the studies reviewed, such as verification bias and poor exclusion criteria, suggesting that results should be approached with caution, and called for more robust research to confirm GPC-3's diagnostic value.
Article Abstract
Objective: Many individual studies have evaluated the diagnostic efficiency of serum glypican-3 (GPC-3) for diagnosing hepatocellular carcinoma (HCC), but the results have been inconsistent. The aim of present study was to meta-analyze the overall diagnostic accuracy of serum GPC-3 for diagnosing HCC.
Design And Methods: English language studies which evaluated the diagnostic performance of GPC-3 and published before March 22, 2013 were retrieved. The quality of the studies was assessed by revised QUADAS tools. The performance characteristics were pooled and determined by random-effects models.
Results: Twelve studies with a total of 898 HCC patients and 835 non-HCC patients were included. For the studies in which the majority of reference participants had HBV or HCV infections, the overall diagnostic sensitivity and specificity were 0.53 (95% CI: 0.49-0.57) and 0.77 (95% CI: 0.74-0.81), respectively. The area under summary receiver operating characteristic (sROC) curves (AUC) was 0.82. The major design deficiencies of included studies were differential verification bias, and a lack of clear exclusion and inclusion criteria.
Conclusions: GPC-3 has moderate diagnostic accuracy for HCC. Due to the design limitations, results in published studies should be carefully interpreted. In addition, more well-designed studies with large sample sizes should be performed to rigorously evaluate the diagnostic value of the GPC-3.
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| http://dx.doi.org/10.1016/j.clinbiochem.2013.12.007 | DOI Listing |
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