AI Article Synopsis
- This study aimed to assess how juvenile zebrafish respond to prolonged exposure to acetylsalicylic acid using oxidative stress biomarkers over a 28-day period.
- Results showed that specific antioxidant enzyme activities, such as glutathione S-transferase and catalase, significantly increased in fish exposed to certain concentrations of acetylsalicylic acid, indicating a protective response against oxidative stress.
- Overall, exposure to acetylsalicylic acid led to enhanced antioxidant enzyme activity and reduced lipid peroxidation, suggesting a potential adaptive mechanism in zebrafish to counteract toxin effects.
Article Abstract
Objectives: The aim of this study was to investigate the effects of subchronic exposure of juvenile development stages of zebrafish (Danio rerio) to acetylsalicylic acid using selected oxidative stress biomarkers.
Design: Toxicity test with acetylsalicylic acid was performed according to the OECD Guideline No. 215, fish D. rerio aged 30 days were used. The tested concentrations were 0.004, 0.4, 40, 120 and 250 mg.L-1, duration of the test was 28 days. Products of lipid peroxidation and antioxidant enzymes were determined as the markers of oxidative stress.
Results: Significantly increased glutathione S-transferase activity was found in fish exposed to acetylsalicylic acid concentrations 40, 120 and 250 mg.L-1. The highest values of glutathione reductase activity were found in the groups exposed to acetylsalicylic acid concentrations 0.4, 40 and 120 mg.L-1. In the group exposed to acetylsalicylic acid concentrations 40 mg.L-1, catalase activity was significantly higher compared to the control group. Significantly higher glutathione peroxidase activity was found in the groups exposed to acetylsalicylic acid concentrations 0.004 and 120 mg.L-1. The concentrations of TBARS were lower in fish exposed to acetylsalicylic acid at all tested concentrations compared to control.
Conclusion: The subchronic exposure of zebrafish to acetylsalicylic acid causes an increase in activity of antioxidant and biotransformation enzymes and a decrease in lipid peroxidation.
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