AI Article Synopsis
- Infections in the female reproductive tract can negatively impact fertility and reproduction.
- The study analyzed the antimicrobial properties of fluids from a cow's reproductive system and found that certain compounds, specifically in the molecular mass range of 3500 to 30,000, were responsible for this activity.
- Histones, particularly H2B type 1-K, were identified as key antimicrobial agents, with their role further validated using specific antibodies.
Article Abstract
An infection of any part of female reproductive tract can severely interfere with fertility and reproduction. The fluids and epithelium from the lumen of the female reproductive tract (uterus, oviduct and ovarian follicle) are a known source of antimicrobial action in several species. In this study, we compared the antimicrobial properties of fluids from the reproductive tract of a cow. After removal of small molecules, we demonstrated that there is an antimicrobial activity connected with a fraction of compounds with a molecular mass range between 3500 and 30,000. The most probable candidates responsible for the observed antimicrobial effect were subsequently identified by mass spectroscopy as histones H2A type 2-C, H2B type 1-K, H3.3, and H4. The antimicrobial role of histone H2B was further confirmed by using an antibody against this histone.
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| http://dx.doi.org/10.1016/j.bbrc.2013.12.077 | DOI Listing |
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