Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against methicillin-resistant Staphylococcus aureus clinical isolate MRSA-108, including hymenocardichromanic acid, which was active at 8 μg/ml. None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2013.11.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lupeol: A Triterpenoid Isolated from the Stem Bark of Hymenocardia Acida (tul.) Exhibits a van der Waal Antagonism on the Alpha Subunit of Gastric H+K+Atpase - A Promising Antiulcer Principle.
Drug Res (Stuttg)
October 2023
Department of Pharmacognosy, University of Benin, Nigeria.
Background: (HA) is one of the numerous medicinal plants in Nigeria with ethnomedicinal history of usage in the treatment of ulcer. The study aimed at isolating antiulcer principle(s) from the stem bark of HA as well as the mechanism of action determination.
Methods: Antiulcer screenings of the crude extract, aqueous fraction, and bulked VLC fractions were performed using and models.
Enhanced Anticancer Activity of Stem Bark Extract Loaded into PLGA Nanoparticles.
Pharmaceuticals (Basel)
April 2022
Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal.
Article Synopsis
- The study investigates the anticancer potential of a well-known African shrub, leveraging nanotechnology to improve the delivery of its bioactive extract.
- Researchers tested the extract's effects on various human cancer cell lines, finding notable cytotoxic activity in both lab models and actual cancer cells.
- While the shrub exhibited anticancer properties, it experienced reduced effectiveness when encapsulated in PLGA nanoparticles, primarily due to the sustained release mechanism.
Prevalence, management and ethnobotanical investigation of hypertension in two Guinean urban districts.
J Ethnopharmacol
March 2019
Department of Pharmacy, University Gamal Abdel Nasser of Conakry, BP 1017, Guinea; Research and Valorization Center on Medicinal Plants Dubreka, BP 6411 Conakry, Guinea. Electronic address:
Ethnopharmacological Relevance: Hypertension is an important public health challenge in low- and middle-income countries, and in many African countries including Guinea medicinal plants are still widely used for its treatment.
Materials And Methods: The objective of this study was to determine the prevalence of hypertension in two Guinean urban districts (Pounthioun and Dowsare), to describe its management and to collect information on traditional herbal remedies. A total of 316 participants entered the study, 28.
Aeroallergens in North-Central Nigeria.
Allergol Immunopathol (Madr)
January 2019
Department of Applied Biology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria.
Introduction And Objectives: Aeroallergens are airborne organic substances which are responsible for allergenic diseases in hypersensitive individuals. People are exposed to their allergens either directly or after their entrance into the interiors. The spatio-temporal pattern of aeroallergens and their relationship with weather variability in Abuja and Nassarawa, North-Central Nigeria was studied.
View Article and Find Full Text PDFIn Vitro and In Vivo Study of the Gastrointestinal Absorption and Metabolisation of Hymenocardine, a Cyclopeptide Alkaloid.
Planta Med
June 2017
Natural Products & Food Research and Analysis (NatuRA), University of Antwerp, Antwerp, Belgium.
Hymenocardine is a cyclopeptide alkaloid present in the root bark of . In traditional African medicine, the leaves and roots of this plant are used to treat malaria, and moderate antiplasmodial activity has been reported for hymenocardine. However, in view of its peptide-like nature, potential metabolisation after oral ingestion has to be taken into account when considering experiments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!