[Effect analysis of multimode analgesia of parecoxib sodium during laparoscopic cholecystectomy].

Objective: To explore the effects of parecoxib sodium multimode analgesia on postoperative analgesia in patients undergoing laparoscopic cholecystectomy (LC).

Methods: A prospective, double-blind, randomized and placebo-controlled study was conducted on 80 patients undergoing elective LC at Department of Endoscopic Surgery, First Affiliated Hospital, Wenzhou Medical College from March 2011 to June 2011. They were randomized to receive either 40 mg parecoxib infusion 30 min preoperative and at 12, 24, 36, 48 h post-operation (treatment group). And 2 ml normal saline infusion was administered similarly as a placebo (control group). All patients received ropivacaine infusion at port sites at the end of LC. The degree of postoperative pain was assessed with visual analog scale (VAS) at 1, 2, 4, 8, 12, 24, 36, 48 h post-operation respectively. The consumption of pethidine in the first 24 h post-operation was also recorded.

Results: The VAS pain scores at each timepoint were significantly lower in the treatment group than those in the control group (1 h: 1.0 ± 0.6 vs 1.8 ± 0.6, t = -1.650, P = 0.000;2 h: 1.3 ± 0.6 vs 1.9 ± 0.7, t = -4.302, P = 0.000; 4 h: 1.6 ± 0.7 vs 2.7 ± 1.2, t = -4.752, P = 0.000;8 h: 2.5 ± 1.4 vs 5.0 ± 1.8, t = -6.835, P = 0.000; 12 h: 2.2 ± 1.1 vs 3.3 ± 1.5, t = -3.902, P = 0.000; 24 h: 1.6 ± 0.8 vs 2.5 ± 1.4, t = -3.649, P = 0.000; 36 h: 1.2 ± 0.6 vs 2.2 ± 0.8, t = -6.390, P = 0.000; 48 h: 1.0 ± 0.5 vs 1.5 ± 0.6, t = -3.710, P = 0.000). And the amount of pethidine used in the first 24h after LC was also less in the treatment group (150 vs 950 mg, χ(2) = 16.200, P = 0.000).

Conclusion: The infusion multimode analgesia of parecoxib sodium 40 mg provides significant effect of postoperative pain relief after laparoscopic cholecystectomy.