AI Article Synopsis
- RAD51C plays a key role in repairing DNA double-strand breaks through homologous recombination, making it significant for cancer research.
- About 1.3% of families with breast cancer (BC) and/or ovarian cancer (OC) not linked to BRCA1/2 have been found to carry mutations in RAD51C.
- There's ongoing debate on whether these mutations also elevate the risk for breast cancer in addition to ovarian cancer, with some studies suggesting a high relative risk for ovarian cancer.
Article Abstract
RAD51C is an integral part of the DNA double-strand repair through homologous recombination, and monoallelic mutations were found in ~1.3% of BRCA1/2-negative breast cancer (BC) and/or ovarian cancer (OC) families. Several studies confirmed the occurrence of RAD51C mutations predominantly in BC and/or OC families, although with varying frequencies, clearly establishing RAD51C as a cancer-predisposing gene. There is ongoing debate whether pathogenic RAD51C alterations increase the relative risk for BC in addition to that for OC, which was estimated to be 5.88 (95% confidence interval = 2.91 to 11.88; P = 7.65 × 10(-7)).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978715 | PMC |
| http://dx.doi.org/10.1186/bcr3589 | DOI Listing |
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