AI Article Synopsis
- Stem cells are special cells that help our bodies grow and heal, and their activity is controlled by signals from nearby cells and the whole body.
- Recent studies show that stem cells can adjust to changes in their environment, like aging or injury, which helps our organs stay healthy.
- This ability to adapt is really important because it allows our bodies to fight off problems and recover when things go wrong.
Article Abstract
Stem cell activity is tightly regulated during development and in adult tissues through the combined action of local and systemic effectors. While stem cells and their microenvironments are capable of sustaining homeostasis in normal physiological circumstances, they also provide host tissues with a remarkable plasticity to respond to perturbations. Here, we review recent discoveries that shed light on the adaptive response of niches to systemic signals and aging, and on the ability of niches to modulate signaling upon local perturbations. These characteristics of stem cells and their niches give organs an essential advantage to deal with aging, injury or pathological conditions.
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| http://dx.doi.org/10.1002/stem.1621 | DOI Listing |
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