Activin B has been reported to promote the regeneration of hair follicles during wound healing. However, its role in the development and life cycle of hair follicles has not been elucidated. In our study, the effect of activin B on mouse hair follicles of cultured and neonatal mouse skin was investigated. In these models, PBS or activin B (5, 10 or 50 ng/ml) was applied, and hair follicle development was monitored. Hair follicle initiation and development was examined using hematoxylin and eosin staining, alkaline phosphatase activity staining, Oil Red O+ staining, and the detection of TdT-mediated dUTP-biotin nick end-labeling cell apoptosis. Activin B was found to efficiently induce the initiation of hair follicles in the skin of both cultured and neonatal mice and to promote the development of hair follicles in neonatal mouse skin. Moreover, activin-B-treated hair follicles were observed to enter the anagen stage from the telogen stage and to remain in the anagen stage. These results demonstrate that activin B promotes the initiation and development of hair follicles in mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000356304 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.
Front Vet Sci
February 2025
Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Secondary hair follicles (SHFs) in cashmere goats produce high-value cashmere fibers, which cyclic regulation is critical for optimizing cashmere yield and quality. This study explores the phenotypic changes and differential protein expression profiles involved in the telogen-to-anagen transition of SHFs. Through histological observations, proteomic analyses, and immunohistochemical validation, we identified key molecular features and regulatory pathways underlying SHF cyclic renewal.
View Article and Find Full Text PDFIKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice.
Exp Dermatol
March 2025
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ikaros, which is encoded by the Ikaros family zinc finger 1 (IKZF1) gene, is a zinc finger transcription factor. We have previously generated K5-Ikzf1-EGFP transgenic mice (Ikzf1 Tg) by introducing the IKZF1 isoform into epithelial cells expressing keratin 5, which develop patchy alopecia. However, there has been no detailed in vivo investigation of the function of IKZF1 in alopecia or of Ikaros expression in hair follicles of alopecia patients.
View Article and Find Full Text PDFA Trichoadenoma/Trichoepithelioma/Trichoblastoma-like Lesion in the Uterine Cervix Focally Mimics an Adenoid Basal Tumor.
Int J Gynecol Pathol
February 2025
Department of Pathology.
The presence of ectodermal adnexal structures in the uterine cervix, including sebaceous glands, hair follicles, and sweat glands, has been well documented in the literature. In theory, there exists the possibility of developing cutaneous-type lesions from the ectopic ectodermal structures in this location. Here we report the first case of cervical hair follicle-derived proliferations reminiscent of trichoadenoma, trichoepithelioma, and trichoblastoma (TA/TE/TB) in a 52-year-old woman who underwent a prophylactic hysterectomy due to a germline microphthalmia-associated transcription factor (MITF) gene mutation.
View Article and Find Full Text PDFHair follicle neural crest stem cells reside in the bulge region of the outer root sheath of hair follicles, originate from the ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineering applications. These cells mainly reside in a hypoxic microenvironment that favors the maintenance of stemness. Recently, many studies have elucidated the involvement of the Hippo pathway in the regulation of stem cell fate.
View Article and Find Full Text PDFIntensive stress impedes hair follicle growth through triggering cell cycle arrest of hair follicle stem cells.
FASEB J
March 2025
Department of Anesthesiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
The detrimental effects of stress on hair growth are supported by empirical and experimental evidence, but the specific impact and mechanisms remain poorly understood. Here we utilized two intensive stress paradigms, repeated resiniferatoxin (RTX) injections and physical restraint in mice, to assess the effects of intensive stress on hair follicle growth after depilation. Initially, macroscopic pictures of the mice dorsal skin and HE staining showed a substantial inhibition of depilation-induced hair growth in both telogen and anagen hair follicle growth under intensive stress induced by RTX and restraint.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!