AI Article Synopsis
- Crohn's disease (CD) and ulcerative colitis (UC) are major types of inflammatory bowel diseases (IBD) whose underlying mechanisms are not fully understood.
- The intestinal epithelium plays a crucial role in managing inflammation and maintaining the integrity of the intestinal barrier, which consists of physical, chemical, and immune components.
- This article aims to explore existing research on how epithelial cells contribute to intestinal balance and their involvement in the development of IBD.
Article Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are the principal inflammatory bowel diseases (IBD) which physiopathology is currently poorly elucidated. During these diseases, the participation of the epithelial cell in the installation and the perpetuation of the intestinal inflammation is now clearly implicated. In fact, the intestinal epithelium located at the interface between the internal environment and the intestinal luminal, is key to the homeostatic regulation of the intestinal barrier. This barrier can schematically be regarded as being three barriers in one: a physical, chemical and immune barrier. The barrier function of epithelial cell can be altered by various mechanisms as occurs in IBD. The goal of this article is to review the literature on the role of the epithelial cell in intestinal homeostasis and its implication in the IBD.
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| http://dx.doi.org/10.1051/medsci/20132912019 | DOI Listing |
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